Nenana /nɛˈnænə/ is a Home Rule City in the Yukon-Koyukuk Census Area of the Unorganized Borough in the Interior of the U.S. state of Alaska. Nenana developed as a Lower Tanana community at the confluence where the tributary Nenana River enters the Tanana. The population was 378 at the 2010 census.Completed in 1923, the 700-foot-long Mears Memorial Bridge was built over the Tanana River as part of the state's railroad project connecting Anchorage and Fairbanks.